Let Your Patients Know

Supplements are complementary to PERT

Let Your Patients Know

Supplements are complementary to PERT

Supplements do not treat EPI but may provide the additional nutrients that your patients with EPI need.1

Many patients with chronic pancreatitis (CP) may eventually develop deficiencies in certain essential nutrients.2,3 Even before developing steatorrhea — or after it's resolved with treatment — patients with CP may be at risk for nutritional deficiencies.1 Normalization of exocrine pancreatic insufficiency (EPI) following pancreatic enzyme replacement therapy (PERT) does not rule out potential nutritional challenges, such as those relating to maintaining healthy bone density and digestion and absorption of fat-soluble vitamins.1 Nutritional deficiency from EPI is also known to increase morbidity and mortality and reduce quality of life in patients with CP.‡4,5

Evidence suggests that a comprehensive nutrition strategy for EPI, with supplements like a multivitamin in addition to PERT, can improve nutritional status.2,6-8

Good starts with nutritional supplements you can trust.

Good starts with nutritional supplements you can trust.

Pure Encapsulations® supplements are designed with integrity in collaboration with nutritional or medical experts — formulated with pure, premium ingredients of the highest quality, and backed by verifiable science. Take the worry out of choosing a supplement for your patients. These are supplements that say what they do and do what they say.

Part of the Nestlé Health Science family of brands, we have spent the last 30 years developing high-quality products that are good to the core, including our professional line of supplements for your patients.

What you say matters.

What you say matters.

Your recommendations play a major role in your patients’ behavior, and that includes your advice on non-prescription medications and supplements.9,10 Why not consider recommending Pure Encapsulations supplements?

PURE transparency. Know what's in our supplements. And what isn't.

Our supplements are FREE FROM GMOs, gluten, unnecessary additives, artificial colors, flavors and sweeteners, and many common allergens including wheat, eggs, peanuts and tree nuts. We offer supplements with the nutrients your patients need, and nothing else.

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EPI Challenges and Pure Encapsulations Supplements


Deficiencies of fat-soluble vitamins are well-documented in patients with CP and should be part of the routine nutritional workup for these patients.1,6,11

*Prevalence of fat-soluble vitamin deficiencies in people with CP: vitamin A in 3–14.5%, vitamin D in 58–77.9%, vitamin E in 9–24%, and vitamin K in 13–63%.7

  • multivitamin (Nutrient 950® with Vitamin K 180s)
  • vitamin A (Vitamin A 3000 mcg)
  • vitamin D (Vitamin D3 Liquid 22.5 mL, Vitamin D3 25 mcg, Vitamin D3 125 mcg)
  • vitamin E (Vitamin E with mixed tocopherols)
  • vitamin K (Synergy K)
Lower levels of micronutrients

Micronutrients, including zinc, magnesium, iron, and selenium, may be lower among patients with CP.1,7,12-15

§Indicates a narrow range.

  • iron (OptiFerin-C 60s)
  • magnesium (UltraMag Magnesium)
  • selenium§ (Selenium citrate)
  • vitamin B12 (B-Complex Plus, B12 Liquid 30 mL, PureMelt B12 Folate 90’s)
  • zinc (UltraZin Zinc 90s)
Bone Health
Approximately 2 out of 3 patients with CP have osteopenia or osteoporosis.1,7
  • calcium (Calcium Magnesium (malate) 2:1 180s, Cal/Mag w/ Cofactors powder 315 g, Cal/Mag/D Liquid 480 mL)
Low essential fatty acids (EFAs)
Patients with EPI may have low levels of EFAs. 31% of patients with chronic gastrointestinal diseases have low levels of EFAs, and the changes to their EFA profiles are similar to the changes seen in patients with CP.16,17 Because essential fatty acids (EFAs) may not be easily digested and absorbed from dietary fats, they must be obtained through diet or supplementation. Omega-3 supplements may provide some nutritional benefit for patients with EPI.17
  • essential fatty acids (O.N.E. Omega)

Stay the course

Remind your patients to continue to take their supplements since they need to meet their daily nutritional needs, even when no symptoms are present.18

See our full list of supplements available to meet your patients' needs
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You can also learn more about the PURE difference.
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1. Löhr JM, Dominguez-Munoz E, Rosendahl J, et al. United European Gastroenterol J. 2017;5(2):153–199.

2. Domínguez-Muñoz JE, Iglesias-García J. JOP. 2010;11(2):158–62.

3. Pham A, Forsmark C. F1000Res. 2018;607:1–11.

4. Domínguez-Muñoz JE. Clin Gastroenterol and Hepatol. 2011;9(7):541–546.

5. O’Brien SJ, Omer E. Nutr Clin Pract. 2019;34(1):S13–S26.

6. Sikkens ECM, Cahen DL, Koch AD, et al. Pancreatology. 2013;13(3):238–242.

7. Arvanitakis M, Ockenga J, Bezmarevic M, et al. Clin Nutr. 2020;39(3):612–631.

8. Ockenga J. HPB. 2009;11(s3):11–15.

9. Doctors play key roles in sales of non-prescription drugs. IPSOS. September 17, 2003. Accessed July 13, 2020. https://www.ipsos.com/en-us/doctors-play-key-role-sales-non-prescription-drugs

10. Vitamins, minerals & supplements: The role of the physician. AccentHealth. October 2014. Accessed July 13, 2020. https://drugstorenews.com/exclusive-content/vitamins-minerals-supplements-role-physician

11. Martínez-Moneo E, Stigliano S, Hedström A, et al. Pancreatology. 2016;16(6):988–994.

12. Vujasinovic M, Hedström A, Maisonneuve P, et al. World J Gastroenterol. 2019;25(5):600–607.

13. Girish BN, Rajesh G, Vaidyanathan K, et al. JOP. 2009;10(6):651–656.

14. Haas S, Krins S, Knauerhase A, et al. JOP. 2015;16(1):58–62.

15. Domínguez-Muñoz E, Castineira M, Larino-Noia J, et al. Gastroenterology. 2010;138(5):S-395.

16. Zeman M, Macášek J, Burda M, et al. Prostaglandins Leukot Essentl Fatty Acids. 2016;108:38–44.

17. Alkaade S, Vareedayah AA. Am J Manag Care. 2017;23(12):S203-S209.

18. Domínguez–Muñoz JE, Iglesias–García J, Vilariño–Insua M, et al. Clin Gastroenterol Hepatol. 2007;5(4):484–488.